Oxalobacter formigenes
- Dataset
- English Wikipedia - Species Pages
- Rank
- SPECIES
Classification
- phylum
- Pseudomonadota
- class
- Betaproteobacteria
- order
- Burkholderiales
- family
- Oxalobacteraceae
- genus
- Oxalobacter
- species
- Oxalobacter formigenes
Abstract
Oxalobacter formigenes is a Gram negative oxalate-degrading anaerobic bacterium that was first isolated from the gastrointestinal tract of a sheep in 1985. To date, the bacterium has been found to colonizes the large intestines of numerous vertebrates, including humans, and has even been isolated from freshwater sediment. It processes oxalate by decarboxylation into formate (oxalyl-CoA decarboxylase), producing energy for itself in the process. The broad-spectrum quinolone antibiotics kill O. formigenes. If a person's gastrointestinal (GI) tract lacks this bacterium, and therefore lacks the primary source for the oxalyl-CoA decarboxylase enzyme, then the GI tract cannot degrade dietary oxalates which on digestion get absorbed easily and after some vitamin B6-modulated partial metabolic degradation in the body, is excreted in the kidney, where it precipitates with calcium to form calcium oxalate kidney stones.(interim reference, describes two other studies)
Oxalobacter formigenes can protect against kidney stones by degrading oxalate. The role and presence of O. formigenes in the human gut is an area of active research.
Oxalobacter formigenes can protect against kidney stones by degrading oxalate. The role and presence of O. formigenes in the human gut is an area of active research.
Name
- Homonyms
- Oxalobacter formigenes